RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation
Abstract Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.Here, we show that the SHIRTS CAREER REGULAR FIT RING finger protein RNF219 co-purifies with the CCR4-NOT complex, the major mRNA deadenylase in eukaryotes, which mediates translational re